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Multiple clinical trials and controlled studies have demonstrated: Statistically significant improvements in skin firmness and elasticity with consistent use Reduction in fine lines and wrinkle depth over 3-6 months of application Improved skin density, moisture retention, and surface texture Reduction in photodamage and hyperpigmentation Tightening of loose skin documented in both topical and injectable applications Citation: Leyden JJ et al

After 12 weeks of application, a significant reduction in fine wrinkles and an improvement in skin texture were documented

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For treating a deficiency, injections are usually given frequently at the start, for example, several times per week or every other day for a couple of weeks, to quickly build up body stores