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Glycemic Control (GLP-1/GIP): Promotes glucose-dependent insulin secretion and suppresses inappropriate glucagon release, leading to improved HbA1c levels
NICE guidance (NG28) specifies that these agents should generally be considered in people with a BMI 30 kg/m (or lower in certain ethnic groups) and specific problems associated with high weight, or if insulin would have significant occupational implications
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Only rodent studies have shown an increased risk of medullary thyroid carcinoma