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Slow dose titration and temporary dose reductions can help lessen fatigue and GI symptoms

Improvement was noted within one month after prescription of topical ZO Retamax (as indicated in the before and after photographs below)

In this process, 5,10-methylene THF play a critical role in methionine regeneration and methyl donation, meanwhile MTHFR catalyzes the irreversible conversion of 5,10-methylene THF to 5-methyl THF that participate in generation of SAM in methionine cycle and offer methyl group 23

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Avoid alcohol and high-fat foods temporarily, as these can intensify nausea