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Neuroprotection and lifespan extension in Ppt1-/- mice by NtBuHA: therapeutic implications for INCL

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2.4.5 NLRP3 Nucleotide-binding oligomerization domain-like pyrin domain-containing protein 3 (NLRP3) is becoming increasingly implicated in the regulation of RF, as evidenced by the significant upregulation of its expression in renal fibrotic tissue (Ke et al., 2018

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Tamoxifen (Sigma Aldrich, T5648) was administered by intraperitoneal injection at 160 mg/kg once daily for 5 days

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