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Conversely, reports suggest that ChaC1 overexpression may be associated with tumor cell dedifferentiation, proliferation, invasion and migration, leading to lower patient survival rates (73,74)
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More importantly, the orally available RNK06395 ERK5-CHAMP showed promising anti-tumor effects, thus representing a potential ERK5-targeting therapy, since many available ERK5 specific small molecule inhibitors and ERK5 PROTAC are ineffective at reducing cancer cell proliferation [41, 42, 47]
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