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This study shows that inhibition of GSK3 by persulfidation counteracts the progression of AD, providing a representative example of the protective effect of persulfidation of key proteins in neurodegenerative diseases

Crit Rev Plant Sci 25:59198 Potters G, Horemans N, Bellone S, Caubergs J, Trost P, Guisez Y, Asard H (2004) Dehydroascorbate influences the plant cell cycle through a glutathione-independent reduction mechanism

doi: 10.3389/fnins.2025.1671955 Received 24 July 2025 Revised 10 December 2025 Accepted 16 December 2025 Published 13 January 2026 Volume 19 - 2025 Edited by Fangchen Gong, Shanghai Jiao Tong University, China Reviewed by Al-Shaimaa Faissal Ahmed, Minia University, Egypt John Sieh Dumbuya, Affiliated Hospital of Guangdong Medical University, China Updates Copyright 2026 Li, Wang, Ma, Peng, Wang, Wang, Li and Wang

Severe skin reactions, although rare, can indicate serious allergic responses or conditions like Stevens-Johnson syndrome

References Katta AV, Suryakar AN, Katkam RV, Shaikh AK, Ghodake SR