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PMID 25187433, retraction notice PMID 40312093), and a third (PMID 23055539) carries a 2021 Expression of Concern
The dosing regimen may depend on the specific patient population, with low-dose, long-term supplementation possibly being sufficient in healthy individuals, whilst patients with end-stage renal disease probably need higher dosages and ideally in combination with folate
Hu, J., Igarashi, A., Kamata, M
Used for years overseas, in athletics, nootropic & regenerative spaces its now fast becoming a staple in many health protocols
Lin and Yao, 2020)
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