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Nature Reviews Drug Discovery , 1-20
The first FDA-approved GLP-1 receptor agonist, exenatide, was introduced for type 2 diabetes in 2005 and required twice-daily injections
These studies showed significant alterations in ceramide levels as well as benzoate, creatine and fatty acid metabolisms and sphingomyelins pathways, with respect to ALS progression 49 , and these changes in metabolite levels correlated with patients ALS Functional Rating Scale (ALSFRS-R) scores 55
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