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Ozempic (semaglutide) was originally approved for the treatment of Type 2 diabetes

It was not until January 2025 that the Ozempic label was updated to state that the drug is "not recommended in patients with severe gastroparesis." Even then, the label does not state that the drug itself may cause the condition

Obesity-related chronic inflammation contributes not only to the alteration of cardiac metabolism, but also to the accumulation of epicardial adipose tissue, which can aggravate the hemodynamic profile and worsen cardiac function

Many patients expect cosmetic surgery to complete their transformation, but the reality is more nuanced

(iii) decrease enterocyte chylomicron production/secretion and (iv) promote -oxidation of NEFAs inside the hepatocytes [79, 81, 82, 86]