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Gao 2023 (human GLP1R-variant series) puts a number on it at the GLP-1 receptor: cAMP output saturates at roughly 10% (103%) receptor surface expression, so full effect sits far below full occupancy

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[20] For nutritional deficiency without intrinsic-factor loss, shorter courses-such as 30-100 mcg intramuscularly daily for five to ten days followed by 100-200 mcg monthly-are often sufficient