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Weight change: 1-2 pounds this week (15-19 pounds total, approximately 8.7% of starting weight)
The American Association of Clinical Endocrinology now recommends considering long-term pharmacotherapy for obesity management
This can weaken the bodys antioxidant defenses, leading to more oxidative damage and a higher risk of multiple myeloma
While studies in cynomolgus monkeys showed that biological aging slowed down, and some data in women suggests it might help people live longer, we still need controlled clinical trials in humans to prove it works as an anti-aging treatment
Key adjustments at this phase: Reduce portion sizes by 20% to 30% across all meals Add a sixth small meal if you cannot finish larger ones Move heavy carbohydrates to earlier in the day when digestion is strongest Switch to softer, easier-to-digest proteins (fish, eggs, Greek yogurt) on dose increase days Keep hydration consistent at 8 to 10 glasses per day, sipped throughout rather than gulped at meals Phase 3: therapeutic doses (10mg, 12.5mg, 15mg, weeks 13+) At higher doses, some people find eating enough to be the challenge, not eating too little
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