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The Blue Cross Blue Shield Federal Employee Program criteria for Saxenda and Wegovy, policy 5.99.030, effective July 1, 2026, require prior participation in a comprehensive weight management program, and at renewal that an adult has lost at least 5 percent of baseline body weight OR the patient has continued to maintain their initial 5 percent weight loss. That is one of the few places in these documents where maintaining rather than losing is written down as a reason to keep paying

A broken Cys182-Cys189 disulfide in AOD-9604 would linearize the peptide and abolish the conformation required for receptor interaction