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Extensive studies have begun to clarify the molecular mechanisms underlying these therapeutic effects, which include anti-aging, immunomodulatory, anticancer, and anti-inflammatory activities
High-intensity exercise also increases the production of free radicals
[12] [13] HRT carries risks including venous thromboembolism (VTE), with transdermal estrogen generally associated with lower VTE risk than oral formulations
Autoxidation of the mitochondrial NO can generate nitrogen dioxide ( NO 2 ) [140]
E.LifshitzL
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