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There is a compelling story around amylin, a protein whose misfolding is a core feature of diabetes

Importantly, this study identified novel candidate genes linked to insulin secretion and T2D risk: ERO1B (ER stress and protein folding), HNRNPA2B1 (an RNA-binding protein regulating insulin levels), and RHOBTB3 (involved in secretory protein trafficking), whose inhibition reduced intracellular insulin (Grenko et al., 2024)

These toxins may come from mold or mold exposure (mycotoxins), volatile organic compounds (VOCs) from new carpet, furniture or cleaning supplies, allergens, and other irritants

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Portal circulation A portal system is one in which veins from one capillary bed drain into another capillary bed, instead of emptying into the heart