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Appetite regulation involves both physiological hunger and cognitive drive, which is why this change can feel noticeable even before significant weight loss occurs

Tirzepatide also supports healthier blood sugar levels, which can help reduce inflammation, improve energy, and support overall metabolic health

They also catch patterns most patients miss, such as undereating during titration weeks or relying too heavily on protein bars at the expense of whole-food protein sources

But for men whose low testosterone is driven primarily by excess body fat and insulin resistance, meaningful weight loss through semaglutide or tirzepatide can produce genuine hormonal improvements alongside the metabolic ones