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Preprint Server Grant support NIH P40OD01995, P30DK034987, P01DK94779 (RBS), Crohns & Colitis Foundation (RBS) Abbreviations AMPK 5-prime-AMP-activated protein kinase Atf/ ATF Activating transcription factor ATP Adenosine triphosphate Cck/ CCK Cholecystokinin CD Crohns disease ClpP Caseinolytic mitochondrial matrix peptidase Dclk Doublecortin-like kinase protein EEC Enteroendocrine cell Gcg/ GCG Glucagon GLP Glucose like protein Hmgcs2/ HMGCS2 3-Hydroxy-3-methylglutaryl-CoA synthase HS Histoscore IBD Inflammatory bowel diseases IEC Intestinal epithelial cell IL Interleukin Isl Insulin gene enhancer protein Mtor Mechanistic target of Rapamycin Ngn/NEUROG Neurogenin Pax Paired box PRKAA Protein kinase AMP-activated catalytic subunit alpha Pyy/PYY Peptide YY Rfx6/ RFX6 Regulatory Factor X 6 Tnf Tumor necrosis factor TPH Tryptophan hydroxylase Trib/TRIB Tribbles pseudokinase UC Ulcerative colitis Wt Wild type Funder Information Declared Footnotes Changes in Figure 1, 2, and 5 References 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11

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Otros sntomas gastrointestinales incluyen vmitos (5-15% de pacientes), diarrea (10-20%), estreimiento (10-20%), dolor abdominal y dispepsia

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Typical daily range: 250500 mcg once daily, raised gradually over a 16-week course