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The percent change in body weight from baseline to week 40 was 4.5% with the 3-mg dose, 5.8% with the 12-mg dose, 7.6% with the 36-mg dose, and 1.7% with placebo

While our data demonstrated clear efficacy for both compounds in reducing alcohol interoceptive effects across the tested dose ranges, it will be important in future work to assess efficacy following repeated treatment and to directly compare potential advantages in terms of efficacy, side-effect profiles, and tolerability

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Therefore, a higher dose of LA may be needed to achieve better effects (either by inhibiting fat synthesis or increasing fat oxidation) in attenuating fatty liver in animals fed a high-fat diet

Track intake for one week using a food scale to rule out portion creep