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64 A 90-day administration of dexamethasone (DEX) resulted in significant declines in both BMD and BMC, along with substantial increases in serum levels of glucose, insulin, triglycerides, total cholesterol, parathyroid hormone (PTH), osteoprotegerin (OPG), and bone resorption markers including deoxypyridinoline (DPD), N-terminal telopeptide of type I collagen (NTX-1), and TRAP-5b
Parallel experiments using the ferroptosis inhibitor liproxstatin-1 show similar protective effects, suggesting that ferroptosis plays a causal role in psoriatic inflammation
DMF has been approved as a first-line treatment for relapsing multiple sclerosis and is used in clinical treatment, with its therapeutic effects partly attributed to the activation of NRF2 [459]
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Human Alzheimer's disease develops over decades with ageing-related comorbidities and systemic factors not present in animal models
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