One study reported that vitamin B12 deficiency was associated with twice the risk of severe depression (4)
Goodman says, though some people require them for the long term. Your healthcare provider will make recommendations based on your B12 level, age, diet and overall health
The Short-Term Timeline: Days 3 to 7 By the end of the first week, the initial surge settles into a steadier supply of B12, and this is often when the more noticeable day-to-day changes appear
You should also contact your GP if: You are unable to attend scheduled maintenance injections, as missing doses can lead to symptom recurrence You develop new symptoms that might indicate other deficiencies or health problems You are planning pregnancy, as B12 requirements may change You experience persistent side effects such as headaches, dizziness, or gastrointestinal symptoms If you experience any side effects, talk to your doctor, pharmacist or nurse
Many patients with tingling or numbness begin to notice a reduction over months two and three, with further recovery beyond six months