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Engineered histidine-rich peptides enhance endosomal escape for antibody-targeted intracellular delivery of functional proteins
This protective effect involves upregulation of antioxidant enzymes and maintenance of mitochondrial membrane potential, indicating Dihexa activates endogenous cellular defense mechanisms that guard against neuronal injury
The drug at the center is Foundayo (orforglipron), Lilly's oral small molecule GLP-1 receptor agonist, FDA approved on April 1
Merck: Notably, Merck has no approved obesity drug in 2025
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