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Some drugs, especially pharmaceuticals like phentermine, may have the following side effects: anxiety/constipation drowsiness, dehydration, and leakage rapidly increasing heart rate insomnia associated with tingling in the limbs Get in touch with your doctor immediately if any of these symptoms persist or worsen

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Real-World Data And What Prescribers Tell Patients Clinicians watch for common adverse effects such as: Nausea Constipation Headaches Counsel patients on: Hydration Titration Symptomatic care Real-world experience mirrors trial data: most side effects are manageable with small behavior changes and medication adjustments

Abbreviations GI: Gastrointestinal PDAC: Pancreatic ductal adenocarcinoma ECM: Extracellular matrix hpCAFs: Human pancreatic cancer associated fibroblasts TME: Tumor microenvironment LFD: Low fat diet HFD: High fat diet OGTT: Oral glucose tolerance test H&E: Hematoxilin/eosin PanIN: Pancreatic intraepithelial neoplasia NGS: Next generation sequencing SEMA: Semaglutide GO: Gene ontology NES: Normalized enrichment score CPTAC: Clinical proteomic tumor analysis consortium ND: Non-dysmetabolic D: Dysmetabolic TCGA: The cancer genome atlas GLP1: Glucagon like peptide 1 GLP1-RA: Glucagon like peptide 1 receptor agonist DEGs: Differentially expressed genes P4HA1: Prolyl 4-hydroxylase subunit alpha 1 E-cad: E-cadherin PanCK: Pancytokeratin aSMA: Alpha smooth muscle actin T2D: Type 2 diabetes GSEA: Gene Set Enrichment Analysis References Kassi E, Pervanidou P, Kaltsas G, Chrousos G

Scientific References National Institute for Health and Care Excellence (NICE)