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In SURPASS-2, where tirzepatide was compared with semaglutide 1 mg in adults on metformin, the 15 mg dose showed a 2.3 percentage point reduction in A1c and an 11.2 kg reduction in body weight at 40 weeks

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Phase I and II clinical trials conducted have shown improved cognitive and motor function with different drugs from GLP-1RA group although the small sized and limited duration of trials have not provided a conclusive result to influence the practice, although with further advancement in ongoing trials effects observed may be noteworthy for intervention in future practice (119)

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