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The CONQUER trial (Gadde et al., 2011) enrolled over 2,400 adults with obesity and at least two weight-related comorbidities, demonstrating that participants receiving the higher-dose combination (phentermine 15 mg/topiramate 92 mg) achieved mean weight loss of approximately 910% of baseline body weight at 56 weeks, compared to 12% with placebo

RABL6A Is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

Individuals with diabetes characterized by HbA1c 6.5%, or a history of surgical or device-based obesity treatment, were excluded