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The CagriSema combination uses 2.4 mg of cagrilintide with 2.4 mg of semaglutide, but reaching these doses requires coordinated titration of both agents
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Recent nationwide cohort studies in Italy and Denmark both found an increased cancer risk in patients with acromegaly
This does not mean subcutaneous is ineffective, but it means you cannot simply transpose a nanomole-per-kilogram IV number to a subcutaneous protocol and expect equivalent CNS exposure
