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The search for interventions that can modulate these pathways more selectively continues, and peptides sit squarely in that investigation

PI3K/AKT/mTOR pathway, as one of the central signaling routes regulated in HPVrelated cancers, was implicated in regulating cell proliferation, migration, invasion, and angiogenesis [83]

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This missing link about the roles of molecular oxidative damage caused by pro-oxidant chemicals, and the antioxidant mechanisms as mediators of the costs of immune activation induced by anti- and pro-inflammatory mechanisms is an important gap in current knowledge 21,22