Time-lapse imaging Videos of freshly isolated mouse tubules stained with 50 nM SYTOX Green nucleic acid stain (Life Technologies) in the presence or absence of 150 nM Biotracker 609 Red Ca 2+ AM dye (Merck Millipore, 5.04297.0001) or 200 nM MitoTracker Red FM (Invitrogen, M22425) were obtained using an oil-immersion 63/0.3 EC Plan Neofluar objective
Unmodified GLP-1(737) was rapidly cleared from circulation, with a plasma half-life of approximately 0.08 hours (4.8 minutes), consistent with the peptides known instability
Careful attention to fluid intake is important, especially during the first weeks of treatment and during dose escalation
Manufactured in a facility that uses ingredients derived from milk (including lactose), soybeans, peanuts, other nuts, sesame seeds, cereals containing gluten, eggs, shellfish, and fish
5.4.1 Effects on adipose tissue GIPRs are abundant in adipose tissue (170)