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Electrospray ionization in positive mode and multiple reaction monitoring are applied for detection

In mouse models of highfat dietinduced liver steatosis, it significantly inhibits hepatic NNMT activity, reduces NAM methylation, increases NAD+ and SAM levels, enhances mitochondrial fatty acid oxidation, reduces hepatic triglyceride and lipid accumulation, lowers lipotoxicity markers (e.g., malondialdehyde, transaminases), improves hepatocellular injury, and reverses steatosis

Countless patients worldwide depend on this treatment, and even the FDA has deemed it safe by adding it to the Category 1 bulks list

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