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Other possibilities are also plausible, as for instance, IGF-I may influence the peripheral immune reaction, what in turn could reduce CNS inflammation, demyelination, and BBB permeability[82]
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The exact biological mechanism by which GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists like tirzepatide might induce dysesthesia or allodynia is not fully understood
Globally, CKD affects 8 to 16% of the population [2], and is very closely associated with adverse clinical outcomes and an increased risk of all-cause mortality [3]
complications and prevention
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