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Mechanistically, the common thread appears to be dampening drug-evoked dopamine signaling in the nucleus accumbens and engaging GLP-1 anti-craving circuits involving the VTA, nucleus accumbens, lateral septum, laterodorsal tegmentum, and nucleus tractus solitarius
Alzheimer Res ., 16 , 622632
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IV therapy delivers 2-6 times higher doses directly to liver tissue, potentially providing even greater benefits
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