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GAPDH, Glyceraldehyde-3-phosphate dehydrogenase

Participants received either a placebo or a dose of tirzepatide in one of three strengths (5 mg, 10 mg or 15 mg)

Initial assessment should include a detailed history characterizing the joint symptoms: onset relative to medication initiation, location and pattern of joint involvement, severity and functional impact, aggravating and relieving factors, and any associated symptoms such as swelling, redness, or morning stiffness

For weight management indications, prescribing guidelines generally require a BMI of 30 or above, or 27 or above with at least one comorbidity such as type-2 diabetes, hypertension, dyslipidaemia, or obstructive sleep apnoea