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GLP-1 adaptation happens relatively quickly, usually within two to three weeks
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doi:10.1371/journal.pone.0040365 Philippova M, Joshi MB, Pfaff D, Kyriakakis E, Maslova K, Erne P, Resink TJ (2012) T-cadherin attenuates insulin-dependent signalling, eNOS activation, and angiogenesis in vascular endothelial cells
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With only a brief analysis of B12 requirements, they recommend vegetarians take a supplement of 250 g per day (Pawlak, 2013)
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