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In MDD, this peripheral-central coupling is likely amplified by BBB dysfunction characterized by increased permeability, neurovascular inflammation, and associations with symptom severity [172, 173] thereby lowering the threshold at which peripheral KP activation translates into central glutamatergic, oxidative, and neuroimmune dysregulation
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Zhang H, Zeng L, Xie M, Liu J, Zhou B, Wu R, et al
People have unpleasant experiences, and theres no evidence of sustained intracellular benefit. Their advocacy centers on modest increases supported by thoughtful human clinical trials, not dramatic delivery methods
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