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in the tissues, O 2 is unloaded from Hb that undergoes a spatial rearrangement of the globin chains, allowing the entry of 2,3-diphosphoglycerate (2,3-DPG) which diminishes O 2 affinity [1, 2]

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Relevant to laboratory studies involving synaptic pathway signaling, dendritic spine biology, neuronal connectivity, and CNS response models

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