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In adults with obesity and knee osteoarthritis, retatrutide delivered: 9mg dose: 26.4% body weight reduction at 68 weeks 12mg dose: 28.7% body weight reduction at 68 weeks (average of 71.2 pounds lost) Placebo: 2.1% body weight reduction The 68-week timeframe is longer than the Phase 2 trial, which partially explains the higher numbers

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Enrolled subjects were randomized to receive one of five possible doses of oral semaglutide once daily (2.5, 5, 10, 20, or 40 mg), placebo, or 1 mg SC semaglutide injection once weekly

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The severity of abdominal pain is unrelated to the impairment of gastric emptying