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Glucosuria also enhances gluconeogenesis and ketogenesis, part of an SGLT2 inhibitor induced shift to a fasting state. Ketogenesis is hypothesized to be a direct mediator of cardioprotection with SGLT2 inhibition since ketone bodies are an efficient energy source with the potential to improve myocardial energy dynamics and exert direct anti-inflammatory effects [1820]
While research is still emerging, there is growing interest in how substantial weight loss may affect the lymphatic system, chronic swelling, inflammation, and overall lymphedema management
However, its important to have realistic expectations and follow a healthy lifestyle for the best weight loss results
44 (1): p
Clinicians should not withhold or discontinue therapy based solely on weight-loss response
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