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The EMA's assessment report on apixaban recommends caution with any agent that inhibits both CYP3A4 and P-gp simultaneously, even modestly, in patients who already have elevated baseline apixaban exposure from renal impairment
GSH converts H 2 O 2 to H 2 O via the action of glutathione peroxidase and requires one mole of NADPH per mole of H 2 O 2
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Clegg LE, Heerspink HJL, Penland RC, et al
