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Bile acids, transformed from primary to secondary forms by bacteria including Clostridium bolteae and Bacteroides, activate TGR5 receptors and antagonize FXR signaling on L cells, both of which promote GLP-1 synthesis and release
Important measures include: Percentage of starting weight lost Waist circumference Hunger and craving control Medication tolerance Protein and calorie intake Strength and physical activity Blood pressure Glucose or hemoglobin A1C when indicated Changes in relevant medications A reduction of at least 5% of starting body weight is considered clinically meaningful and may improve several obesity-related health risks
R.PatelH
No bowel movement for more than three days despite using laxatives and dietary modifications
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