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Disturbances in components in the p53/MDM2/IGF-1R network may cause IGF-1R upregulation and growth advantage for the cancer cell
Similarly, chitosan-modified PLGA NPs co-encapsulating liraglutide and alogliptin normalized glycemia for 24 h post-oral administration in STZ-induced diabetic rats, underscoring improved glucose regulation and the translational promise of non-invasive delivery routes [416]
Additionally, a case report highlighted that liraglutide therapy, in contrast to insulin, reduced C-peptide (CPR) concentrations and improved glucose control, along with enhanced quality of life for a patient with T2DM and active CD [228]
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