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However, in contrast to the short and medium-chain acylcarnitines (Table S2), the mean concentration of these 13 long-chain acylcarnitines was significantly lower in the patients (2.67 0.0.87 mol/L) than that in the healthy controls (3.15 0.93 mol/L), and the difference between the two groups generated a significant P-value of 0.0014

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(39407841) overall epidemiology Pyroglutamic acidosis is rare, with only ~130 reported cases in the literature

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In line with our observation, activation of p38 with preconditioning stimuli or over-expression of MKK3/MKK6 has been reported to protect the heart against myocardial I/R injury [5358]