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Semaglutide had consistent beneficial effects on all secondary efficacy endpoints (including six-minute walk distance) across diuretic subgroups (p interaction=0.24-0.92)
When considering current recommendations from the ADA for add-on therapy to metformin in patients not achieving individualized glycemic goals, PIONEER 2 provides valuable data comparing the addition of either an oral GLP-1 receptor agonist or an SGLT-2 inhibitor
Diabet Med J Br Diabet Assoc
Reduction in Inflammation: It has been observed to potentially reduce inflammation by modulating immune responses and promoting tissue repair
The exogenous drug operates at much higher concentrations than natural incretin hormones, and its six-day half-life means it is active around the clock regardless of when it peaks
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