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Limitations of animal research: Rat healing faster than human, young research animals heal better than aged humans, controlled injury models don't replicate complex human injuries perfectly, dosing conversions uncertain (body weight scaling imperfect), immune system differences affect inflammation and healing
Still, larger studies, including patients from other parts of the world and a longer treatment period, are needed to validate methylcobalamins therapeutic effects in this subset of ALS patients, the authors noted.
This pattern suggests GHK-Cu provided temporary stimulation rather than inducing self-sustaining structural changes, requiring continuous or cyclical application for maintaining optimal results
1994 Sept;47(9):1021-26