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Metformin remains the first-line treatment for PCOS patients with metabolic issues
In fat cells, it increases thermogenesis and lipolysis, further driving the conversion of free fatty acids to ketone bodies
Good sources of soluble fiber include vegetables, fruits, and whole grains
Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor Carbenoxolone
Given that ErbB contributes to IGF-IR/InsR and ER antagonist resistance, co-targeting ErbB, IGF-IR/InsR, and ER may achieve maximal anti-cancer effect on ER+ breast cancer [110]
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