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In the REDEFINE 1 clinical trial, patients treated with the combination achieved a mean weight loss of 22.7% at 68 weeks, and more than 40% of participants achieved at least a 25% reduction in body weight

PMC 5711500

Now it seems oral small-molecule GLP-1s also dial back eating for pleasure by engaging a brain reward circuit. Given the effect of these drugs on eating for pleasure, future studies could explore whether small-molecule GLP-1s can also suppress cravings for other addictive substances

The label might read "Semaglutide 2.5 mg / Cyanocobalamin 1 mg per mL." The B12 does not change the semaglutide concentration

Symptoms tend to become more obvious as the disease progresses