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S.MahmoodzadehH.SharifS
PMID: 41575937 bioRxiv2024 June 12
Diab Care 36 , 13961405 (2013)
Specifically, the biosynthesis of amino acids (37 KOs), was significantly down-represented, including cysteine and methionine metabolism ( metA , metB , metK , mtnN , thrB , cysK , patB and L-serine dehydratase ), the biosynthesis of lysine ( dapA , dapB , dapE , dapH , dapL , argD , patA and lysA ), the metabolism of histidine ( hisA , hisB , hisE , hisH and hisI ), glycine, serine and threonine ( glyA , thrB , thrC and L-serine dehydratase ), alanine, aspartate and glutamate (asnA, asnB and argH), the biosynthesis of phenylalanine, tyrosine and tryptophan ( aroD and aroE ) and the biosynthesis of arginine ( argD and argH )
What we know from phase 2 The 48-week phase 2 trial provided reassuring safety signals
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