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More recently, the potential health advantages of these drugs have expanded
Liraglutide and dulaglutide, as GLP-1R agonists, can improve AD-related cognitive dysfunction by inhibiting tau protein hyperphosphorylation and NFTs formation through activation of the protein kinase B/glycogen synthase kinase 3 beta (Akt/GSK-3) signaling pathway (Shu et al., 2019
Ive been a PI on several GLP-1 trials for the last 15 years, but their current marketed indications are only from the last two to three years. The dual agonist GIP + GLP-1 (tirzepatide) and high-dose semaglutide are approved specifically for non-diabetic obesity: BMI above 25 with one comorbidity, or BMI above 30 with no comorbidities or diabetes
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Only 4.2% of participants discontinued due to side effects after week 24, indicating that side effects become manageable or resolve entirely for the vast majority who continue treatment
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