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They mimic the effects of the natural hormone GLP-1, stimulating insulin release, reducing glucagon secretion, and slowing gastric emptying
Semaglutide sold as Wegovy is currently the most commonly prescribed GLP-1 medication for managing obesity
Groups 4 and 5 (semaglutide 1.0 mg and 2.4 mg, respectively) discontinued placebo infusions
Although GLP-1s are generally well tolerated, with common side effects including gastrointestinal issues like nausea, vomiting, diarrhea and constipation, rare, more serious complications include issues like stomach paralysis, pancreatitis, bowel obstruction, kidney failure and thyroid cancer
When the study concluded, participants taking orlistat lost around 10.3 kg (22 lbs) after the year, significantly more than the placebo group
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