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Lifestyle and Dietary Considerations While GLP-1 therapy can be highly effective in managing blood sugar and promoting weight loss, it is not a substitute for healthy lifestyle choices

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Although current evidence supports broad applicability across BMI, diabetes status, and fibrosis stages F2-F3, subgroup analyses suggest attenuated responses in non-obese patients and in certain ethnic groups (Hispanic patients in ESSENCE), emphasizing the need for precision medicine approaches incorporating anthropometric, genetic (e.g., PNPLA3, HSD17B13), and metabolic profiling

Fibre is fermented by gut bacteria into short-chain fatty acids, which activate other receptors (FFAR2 and FFAR3) that also trigger GLP-1 release

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