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As described in studies published shows these drugs mimic natural hormones that signal satiety to the central nervous system
But the gap is large enough that it is hard to explain away with population differences alone
Population studies across Indian states report an MTHFR C677T T-allele frequency of roughly 817%, which is notably lower than the 3045% seen in Caucasian and East Asian populations
You should aim for a moderate deficit (500 to 750 calories below maintenance) rather than the extreme deficits that appetite suppression can create
Those needing a high-dose supplement
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