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In addition, the overexpression of ZIP8 results in the increase of zinc influx in chondrocytes, which enhances the activity of zinc dependent matrix metalloproteinases, inducing cartilage rupture
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A positive response was registered if animals displayed nociceptive behavior, such as rapid withdrawal of the paw, licking, or shaking the paw during filament application or immediately after filament removal
Limited, well-timed use around surgical repair, embryo transfer, or ovulation could still exploit the pro-repair and angiogenic effects while minimizing systemic exposure
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