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In response to different extracellular stimuli, the complex may dissociate and JNK can phosphorylate c-Jun, a component of the activator protein-1 transcription factor

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When toxic exposure, gut-derived inflammation, low zinc, oxidative stress, low SAM or elevated SAH exceed the livers metabolic reserve, detoxification may become less efficient and contribute to fatigue, brain fog, mood symptoms and toxic overload